Altered Expression of Toll-Like Receptors and Key Signaling Genes in Sertoli Cells of Azoospermic Patients
Altered expression of TLRs and associated signaling molecules in Sertoli cells of azoospermic men suggests innate immune dysregulation as a potential mechanism underlying defective spermatogenesis. These findings highlight immune privilege-associated pathways as possible targets for developing diagnostic biomarkers and novel therapeutic approaches for male infertility.
Authors
- Mohammad Ali Sadighi Gilani (ORCID: https://orcid.org/0000-0001-6168-8599)
- Reza Hajihosseini (ORCID: https://orcid.org/0000-0003-0953-233X)
- Reza Aflatoonian
- Marjan Sabbaghian (ORCID: https://orcid.org/0000-0001-9439-268X)
- M R Lakpour
Institutions
- Royan Institute (IR)
- Academic Center for Education, Culture and Research (IR)
- Payame Noor University (IR)
- Shahid Beheshti University of Medical Sciences (IR)
Publication Details
- Journal
- Journal of Reproduction & Infertility
- Published
- 2025-08-30
- DOI
- https://doi.org/10.18502/jri.v26i2.19436
- Primary Topic
- Sperm and Testicular Function
- Type
- article
- Field-Weighted Citation Impact
- 0.00