Influenza A Infection Increases Severity of Acute Ischemic Stroke Through Neutrophil Activation and Hypercoagulability
These findings suggest that IAV infections enhance the systemic propensity for NETosis and foster a procoagulant state, thereby increasing the risk of cerebral damage and thrombosis following stroke. Targeting a combination of neutrophils and coagulation molecules simultaneously represents a promising treatment approach for clinical stroke.
Authors
- Christoph Kleinschnitz (ORCID: https://orcid.org/0000-0002-1650-8875)
- Steffen Haupeltshofer (ORCID: https://orcid.org/0000-0002-7002-9760)
- Torben Knuschke (ORCID: https://orcid.org/0000-0002-2273-1475)
- Friederike Langhauser (ORCID: https://orcid.org/0000-0002-6515-6191)
- Philine Steinbach (ORCID: https://orcid.org/0000-0001-7533-1881)
- Astrid Maria Westendorf (ORCID: https://orcid.org/0000-0002-2121-2892)
- Wiebke Hansen (ORCID: https://orcid.org/0000-0002-6020-0886)
- Fabian Szepanowski (ORCID: https://orcid.org/0000-0003-3071-4269)
- Ana I. Casas (ORCID: https://orcid.org/0000-0002-0935-074X)
- Anne K. Mausberg (ORCID: https://orcid.org/0000-0001-9026-1703)
- Alina Blusch (ORCID: https://orcid.org/0000-0003-4813-8183)
- Christina Wenzek (ORCID: https://orcid.org/0000-0002-9693-4400)
- Christina Hansmann
Institutions
- Center for Personalized Cancer Treatment (NL)
- Department of Health (TW)
- Essen University Hospital (DE)
- Wallenberg Wood Science Center (SE)
Publication Details
- Journal
- Stroke
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1161/strokeaha.125.052967
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.00