MFN2 and BAG6 Synergistically Protect Against Cerebral Reperfusion Injury by Regulating ROS Levels and Autophagic Flux
Our study suggests that MFN2 enhances stroke outcome through 2 pathways: by decreasing ROS levels and modulating autophagy via interaction with BAG6. BAG6 potentiates the ROS-lowering, cytoprotective MFN2 actions. The MFN2-BAG6 axis represents a promising target for stroke therapy.
Authors
- Dirk M. Hermann (ORCID: https://orcid.org/0000-0003-0198-3152)
- Britta Kaltwasser
- Xingyun Quan
- Ulf Brockmeier
- Qinlian Ye
- Guodong Huang (ORCID: https://orcid.org/0000-0002-2848-7581)
- Yachao Wang (ORCID: https://orcid.org/0000-0003-3709-5368)
- Yukun Yang (ORCID: https://orcid.org/0009-0006-5895-1548)
- Yanfen Liu (ORCID: https://orcid.org/0000-0002-1192-8328)
- Danbo Lu (ORCID: https://orcid.org/0000-0003-4753-335X)
Institutions
- Guangxi University (CN)
- ShanghaiTech University (CN)
- Guangxi University of Chinese Medicine (CN)
- Essen University Hospital (DE)
- Shenzhen Second People's Hospital (CN)
- University of Duisburg-Essen (DE)
Publication Details
- Journal
- Stroke
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1161/strokeaha.125.052689
- Citations
- 4
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.22