Butyric acid and valeric acid attenuate stress-induced ferroptosis and depressive-like behaviors by suppressing hippocampal neuroinflammation
Stress induces ferroptosis in hippocampal neurons, where reduced abundance of short-chain fatty acid-producing bacteria plays a key role. Key metabolites butyric acid and valeric acid alleviate neuroinflammation to improve ferroptosis via the gut-brain axis in acute and chronic stress, respectively. Specifically, valeric acid exerts neuroprotective effect through the GPR41/RhoA/Rock1 pathway, whereas butyric acid-mediated protection likely operates through alternative mechanisms.
Authors
- Weihao Zhu
- Lin Wu (ORCID: https://orcid.org/0000-0003-1472-8759)
- Xiaowei Feng (ORCID: https://orcid.org/0000-0002-8666-9383)
- Weibo Shi (ORCID: https://orcid.org/0000-0001-9601-3188)
- Zhen Wang (ORCID: https://orcid.org/0000-0002-8182-2852)
- Shujin Li (ORCID: https://orcid.org/0000-0002-7691-3776)
- Yingmin Li (ORCID: https://orcid.org/0000-0002-1269-173X)
- Xiaoying Ma
- Bin Cong (ORCID: https://orcid.org/0000-0003-3349-7204)
- R. Ma (ORCID: https://orcid.org/0000-0002-8065-5992)
Institutions
- Hebei Medical University (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s12967-025-06950-0
- Citations
- 3
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Natural Science Foundation of China