Sex- and age- differences in the expression of critical blood-brain barrier regulators: a physiological context
This study systematically analyzes the expression characteristics of key BBB regulatory genes in different sexes and ages under physiological conditions and reveals a marked sex difference in the expression of BBB structure/function-related genes, which may persist with the advancing age. The findings may provide important theoretical insights into the pathogenesis of sex-and age-related neurological diseases.
Authors
- Xiaoman Dai (ORCID: https://orcid.org/0000-0003-3409-5936)
- Xue Mi (ORCID: https://orcid.org/0000-0002-7855-3030)
- Zi-Ling Ye
- Xujun Zhang (ORCID: https://orcid.org/0000-0002-1789-5926)
- Xiaochun Chen (ORCID: https://orcid.org/0000-0002-2665-4155)
Institutions
- Fujian Medical University (CN)
Publication Details
- Journal
- Biology of Sex Differences
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s13293-025-00751-2
- Citations
- 3
- Primary Topic
- Barrier Structure and Function Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- Natural Science Foundation of Fujian Province
- Fujian Medical University