ATE1 promotes breast cancer progression via arginylation-dependent regulation of MAPK-MYC signaling
ATE1 promotes breast cancer progression by enhancing cell proliferation, survival, and migration through MAPK-dependent stabilization of MYC in a lineage-specific context. These findings identify ATE1 as a potential therapeutic target and highlight the relevance of protein arginylation in the molecular heterogeneity of breast cancer.
Authors
- Bo Yeon Kim (ORCID: https://orcid.org/0000-0003-1105-5480)
- Nak‐Kyun Soung (ORCID: https://orcid.org/0000-0002-7325-308X)
- Jung Gi Kim (ORCID: https://orcid.org/0000-0002-3423-5401)
- Laxman Nawale (ORCID: https://orcid.org/0000-0002-9538-6561)
- Hyunjoo Cha‐Molstad (ORCID: https://orcid.org/0000-0003-3676-7150)
- Shinyeong Ju (ORCID: https://orcid.org/0000-0001-5483-4690)
- Cheolju Lee
Institutions
- Biocon (Switzerland) (CH)
- Korea Institute of Science and Technology (KR)
- Korea Research Institute of Bioscience and Biotechnology (KR)
- Korea University of Science and Technology (KR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s12964-025-02376-9
- Citations
- 2
- Primary Topic
- RNA modifications and cancer
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- National Research Foundation
- Korea Research Institute of Bioscience and Biotechnology
- National Research Foundation of Korea
- Ministry of Science and ICT, South Korea