Figure 5 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models
<p>Dietary cellulose tends to negatively affect ICB efficacy in <i>Pold1</i><sup>D400A/D400A</sup> mice. <b>A,</b> Schematic showing <i>Pold1</i><sup>D400A/D400A</sup> study design. <b>B,</b> Survival curves of <i>Pold1</i><sup>D400A/D400A</sup> mice fed with the indicated HC or LC diets and treated with isotype control or anti–PD-1 antibody. Shown are plots for both sexes combined and males and females separately. <i>n</i> = 11 to 13, <i>n</i> = 6 to 8, and <i>n</i> = 5 to 6 mice per group for both sexes, males, and females, respectively. Overall survival curves are not significantly different. (<b>A,</b> Created with <a href="http://sciencefigures.org" target="_blank">sciencefigures.org</a>.)</p>
Authors
- Zihong Chen (ORCID: https://orcid.org/0000-0002-1554-1649)
- Eric G. Pamer (ORCID: https://orcid.org/0000-0002-6755-9904)
- Asael Roichman (ORCID: https://orcid.org/0000-0001-9538-0103)
- Victoria Burgo (ORCID: https://orcid.org/0000-0003-1016-3199)
- Yibin Kang (ORCID: https://orcid.org/0000-0002-1626-6730)
- Michael R. MacArthur (ORCID: https://orcid.org/0000-0003-3593-6995)
- Joshua D. Rabinowitz (ORCID: https://orcid.org/0000-0002-1247-4727)
- Yong Wei (ORCID: https://orcid.org/0000-0002-1034-649X)
- Akshada Sawant (ORCID: https://orcid.org/0000-0001-9878-4445)
- Ziqing Chen (ORCID: https://orcid.org/0000-0001-5077-2250)
- Gabriela Reyes‐Castellanos
- Eileen White (ORCID: https://orcid.org/0000-0003-2961-3065)
- Sarah J. Mitchell
- Beianka Tomlinson
- Xincheng Xu (ORCID: https://orcid.org/0000-0003-1062-2092)
- Maria Gomez-Jenkins (ORCID: https://orcid.org/0000-0003-3682-9219)
- Jesse R. Powers
- Xiang Hang
- Maria Ibrahim
- Llewelyn Levett
Publication Details
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1158/0008-5472.30029893
- Primary Topic
- Esophageal Cancer Research and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00