Figure 2 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

<p>Purified diet has a greater impact than fiber on the serum and fecal metabolome. <b>A,</b> PCA of serum metabolomics from the B16-OVA experiment. PC, principal component. <b>B,</b> Heatmap showing log-transformed relative abundances of top 50 significant metabolites by ANOVA of the same metabolomics dataset. <b>C,</b> Volcano plots of serum metabolites in mice fed with chow vs. low–fiber-purified diet (LC_In0) and in mice fed with high–fiber (HC_In8)- vs. low–fiber (LC_In0)-purified diet (all B16-OVA tumors and anti–PD-1 treatment). FC, fold change. <b>D,</b> Venn diagram of significantly changed metabolites from the comparisons shown in <b>C</b>, showing minimal overlap between the high–fiber-purified diet and chow. For all panels, <i>n</i> = 7 to 8 mice per group.</p>

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Publication Details

Published
2025-09-02
DOI
https://doi.org/10.1158/0008-5472.30029902
Primary Topic
Esophageal Cancer Research and Treatment
Type
article
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article

Figure 2 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Zihong Chen, Eric G. Pamer, Asael Roichman, Victoria Burgo et al.
Esophageal Cancer Research and Treatment
article

Figure 2 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

Zihong Chen, Eric G. Pamer, Asael Roichman, Victoria Burgo, Yibin Kang, Michael R. MacArthur, Joshua D. Rabinowitz, Yong Wei, Akshada Sawant, Ziqing Chen, Gabriela Reyes‐Castellanos, Eileen White, Sarah J. Mitchell, Beianka Tomlinson, Xincheng Xu, Maria Gomez-Jenkins, Jesse R. Powers, Xiang Hang, Maria Ibrahim, Llewelyn Levett
article en

Abstract

<p>Purified diet has a greater impact than fiber on the serum and fecal metabolome. <b>A,</b> PCA of serum metabolomics from the B16-OVA experiment. PC, principal component. <b>B,</b> Heatmap showing log-transformed relative abundances of top 50 significant metabolites by ANOVA of the same metabolomics dataset. <b>C,</b> Volcano plots of serum metabolites in mice fed with chow vs. low–fiber-purified diet (LC_In0) and in mice fed with high–fiber (HC_In8)- vs. low–fiber (LC_In0)-purified diet (all B16-OVA tumors and anti–PD-1 treatment). FC, fold change. <b>D,</b> Venn diagram of significantly changed metabolites from the comparisons shown in <b>C</b>, showing minimal overlap between the high–fiber-purified diet and chow. For all panels, <i>n</i> = 7 to 8 mice per group.</p>

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Figure 2 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models — Zihong Chen, Eric G. Pamer, et al. · (2025) | TGRS Research Map | TGRS