Figure 4 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

<p>Purified cellulose enhances response to ICB therapy in YUMM1.1-9 but not in B16-OVA melanoma allografts. <b>A</b> and <b>B,</b> Mean tumor volumes and fraction of mice free of tumors larger than 500 mm<sup>3</sup> for subcutaneous YUMM1.1-9 allografts in mice fed with chow or the indicated purified diets and treated with isotype control (for chow) or anti–PD-1. <i>n</i> = 9 to 11. <b>C</b> and <b>D,</b> Similar independent experiment for mice fed with chow, LC-, or HC-purified diets and treated with isotype control or anti–PD-1 antibody. <i>n</i> = 11. <b>E</b> and <b>F,</b> Mean tumor volumes and the fraction of mice free of tumors larger than 2,000 mm<sup>3</sup> for subcutaneous B16-OVA allografts in mice fed chow or the indicated purified diets and treated with isotype control (for chow) or anti–PD-1. <i>n</i> = 7 to 12. *, <i>P</i> < 0.05; **, <i>P</i> < 0.01 for <b>A</b>, <b>C</b>, and <b>E</b> by a two-way ANOVA with the Tukey <i>post hoc</i> test at endpoint; values are mean ± SEM. For <b>B</b>, <b>D</b>, and <b>F</b>, log-rank test.</p>