Supplementary Figure 6 from Anti-HER2, High-DAR Antibody Fragment–Drug Conjugates with a Glucuronide-Based MMAE Linker–Payload Demonstrate Superior Efficacy over IgG-Based ADCs
<p>Supplementary Figure 6 showing (a to c) binding of the scFv, FDC, IgG and ADC to CD64, CD32 and CD16 Fc-Gamma Receptors by SPR and (d) binding of the same test molecules to human monocytes extracted from PBMCs</p>
Authors
- Ioanna Stamati
- Bryan Edwards
- Laura Bouché
- Gökhan Yahioglu (ORCID: https://orcid.org/0000-0003-4043-4914)
- Sam Ness
- Antony Constantinou
- Isabel Perez-Castro
- Benjamin J. Stenton (ORCID: https://orcid.org/0000-0001-5852-2803)
- Mahendra P. Deonarain (ORCID: https://orcid.org/0000-0002-2936-169X)
- Savvas Saouros
- Anja Pomowski
- Soraya Diez-Posada
- A. Keith Stewart
Publication Details
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1158/1535-7163.30029702
- Primary Topic
- Monoclonal and Polyclonal Antibodies Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00