Figure S4 from Inhibition of <i>MCL-1</i> and MEK Overcomes MEK Inhibitor Resistance in Triple-Negative and Inflammatory Breast Cancers
<p>Fig. S4 Effect of combination of drugs on SUM149-R cells. The clonogenic assay shows a significant dose-dependent decrease in the colony formation capability of SUM149-R cells after treatment with the combination of MEKK inhibitor AZD6244 and MCL-1 inhibitor S63845 at the same time.</p>
Authors
- Mary Kathryn Pitner (ORCID: https://orcid.org/0009-0004-7423-6072)
- Chandra Bartholomeusz (ORCID: https://orcid.org/0000-0002-5806-1557)
- Wendy A. Woodward (ORCID: https://orcid.org/0000-0002-7935-739X)
- Geoffrey Bartholomeusz (ORCID: https://orcid.org/0000-0002-4622-4195)
- Lajos Pusztai (ORCID: https://orcid.org/0000-0001-9632-6686)
- Varsha Gandhi (ORCID: https://orcid.org/0000-0002-3172-9166)
- Moises Tacam (ORCID: https://orcid.org/0000-0002-9292-1020)
- Savitri Krishnamurthy (ORCID: https://orcid.org/0000-0001-9030-4136)
- Jian Wang (ORCID: https://orcid.org/0000-0001-7104-0673)
- Bisrat G. Debeb (ORCID: https://orcid.org/0000-0002-8227-2266)
- Emilly S. Villodre (ORCID: https://orcid.org/0000-0002-3092-7013)
- Bora Lim (ORCID: https://orcid.org/0000-0002-4182-6058)
- Mohd Mughees (ORCID: https://orcid.org/0000-0002-5533-8135)
- Rachel M. Layman (ORCID: https://orcid.org/0000-0002-8663-0331)
- Takahiro Kogawa (ORCID: https://orcid.org/0000-0003-3730-6591)
- LaKesla R. Iles (ORCID: https://orcid.org/0000-0001-6992-7910)
- Naoto Tada Ueno (ORCID: https://orcid.org/0000-0002-0166-7275)
- Yuan Qi (ORCID: https://orcid.org/0000-0001-9718-7593)
- Xiaoding Hu (ORCID: https://orcid.org/0000-0002-3144-1859)
- Debu Tripathy (ORCID: https://orcid.org/0000-0002-5711-2404)
Publication Details
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1158/1535-7163.30029540
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00