Figure 6 from Dietary Fiber Lacks a Consistent Effect on Immune Checkpoint Blockade Efficacy Across Diverse Murine Tumor Models

<p>High–fiber-purified diet, but not chow, modestly enhances ICB efficacy in a breast cancer mouse model. <b>A,</b> Mean tumor volumes (calculated as the total volume of all individual mammary tumors per mouse) of MMTV-PyMT mice fed the indicated diets, with or without anti–PD-1 treatment. <b>B,</b> Fraction of mice free of a single primary tumor larger than 2,000 mm<sup>3</sup>. For <b>A</b> and <b>B</b>, <i>n</i> = 5 for isotype control and <i>n</i> = 10 for anti–PD-1 groups. <b>C</b> and <b>D,</b> Percentage of neutrophils and B cells among CD45<sup>+</sup> cells in primary tumors collected at endpoint. <i>n</i> = 6 to 8 tumors collected from five mice for no treatment and 10 to 12 tumors from nine mice for anti–PD-1. *, <i>P</i> < 0.05. The log-rank test for <b>B</b> and an ANOVA with the Tukey <i>post hoc</i> test for other panels. Values are mean ± SEM.</p>