Spatial transcriptomics of retinoblastoma: a visual window on intra-patient heterogeneity
This study demonstrates a strong correlation between histological observation and molecular profiling, representing the first mapping of retinoblastoma composed of adjacent molecular subtypes 1 and 2. It also highlights the diagnostic ambiguity between retinocytoma and well-differentiated non-proliferative subtype 1 retinoblastoma and emphasizes the need for specific biomarkers to differentiate these two tumor types.
Authors
- Adeline Berger (ORCID: https://orcid.org/0000-0003-2986-4489)
- Christina Stathopoulos (ORCID: https://orcid.org/0000-0001-8465-2716)
- L. Mazzeo
- Alexandre Moulin
- Julien Thévenet (ORCID: https://orcid.org/0000-0001-6873-8640)
- Francis L. Munier (ORCID: https://orcid.org/0000-0002-8928-1050)
- S. Tissot
Institutions
- Hôpital Orthopédique de la Suisse Romande (CH)
- Fondation Asile des Aveugles (CH)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s12885-025-14814-5
- Primary Topic
- Ocular Oncology and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Université de Lausanne