IN VITRO EVALUATION OF THROMBOLYTIC ACTIVITY OF ETHANOLIC EXTRACT OF AEGLE MARMELOS FRUIT

Considering the limitations of conventional thrombolytic agents, such as cost and adverse effects, the potential of herbal alternatives was investigated. This study evaluated the thrombolytic activity of the ethanolic extract of Aegle marmelos (Bael) fruit, traditionally used in Indian medicine. The extract was prepared through ethanolic reflux, and its thrombolytic activity was assessed using an in vitro clot lysis assay. Results showed a dose-dependent increase in clot dissolution, with the extract achieving 75.26% clot lysis at 500 µg mL-1, compared to 99.85% for streptokinase. These findings demonstrate significant clot-dissolving potential, suggesting the presence of bioactive constituents with fibrinolytic properties. The present findings warrant further investigation aimed at the isolation of bioactive compounds and the validation of their therapeutic efficacy.