Human papillomavirus-related syntaxin 11 reprograms tumor-associated macrophages to induce breast cancer cell apoptosis via PI3K/AKT signaling
HPV-related risk signatures were constructed, which showed prognostic predictive ability for patients with BC. STX11 is associated with a favorable prognosis in patients with BC and facilitates M1 polarization, and macrophages overexpressing STX11 can inhibit BC malignancy by regulating the PI3K-AKT pathway, suggesting its role as a potential immunotherapeutic candidate.
Authors
- Zengrong Jia
- Chuan Hu (ORCID: https://orcid.org/0009-0007-2529-5334)
- Jianguo Wen (ORCID: https://orcid.org/0000-0003-0952-118X)
- Tingting Hu (ORCID: https://orcid.org/0000-0001-8017-2619)
Institutions
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- Zhejiang Cancer Hospital (CN)
- Netherlands Heart Registration (NL)
- Cancer Hospital of Chinese Academy of Medical Sciences (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Molecular Medicine
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s10020-025-01325-z
- Citations
- 2
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- China Postdoctoral Science Foundation