Data from The Impact of Edema on Skeletal Muscle Changes among Patients with Pancreatic Ductal Adenocarcinoma

<div>AbstractBackground:<p>Muscle loss influences pancreatic ductal adenocarcinoma (PDAC) outcomes, but treatment-related edema may cause overestimation of total skeletal muscle area (tSMA), confounding our understanding of muscle changes. However, no studies have quantified the impact of edema on tSMA and psoas skeletal muscle area (pSMA) changes. Thus, we sought to (i) assess the impact of edema on tSMA and pSMA changes between diagnosis and follow-up and (ii) explore the utility of pSMA as a clinically relevant measure of muscle and muscle loss among patients with PDAC.</p>Methods:<p>Body composition was measured using CT scans at diagnosis and follow-up from 95 patients enrolled in the Florida Pancreas Collaborative cohort study. Edema was assessed by opacifications in subcutaneous fat, and tSMA and pSMA changes were expressed as percent change between diagnosis and follow-up. We used multivariable generalized linear models to estimate mean tSMA and pSMA changes overall and by edema status. Spearman correlation was used to measure interrelationships of tSMA and pSMA.</p>Results:<p>tSMA increased between diagnosis and follow-up (Δ = 0.66) but only in patients with edema (Δ = 3.35) whereas non-edematous patients lost tSMA (Δ = −2.03). Conversely, pSMA decreased regardless of edema status. Furthermore, tSMA and pSMA were strongly correlated overall (<i>r</i> = 0.75) and in non-edematous patients (<i>r</i> = 0.83).</p>Conclusions:<p>Edema inflated estimates of tSMA at follow-up in patients with PDAC, but pSMA was impervious to edema and may represent a suitable proxy for tSMA.</p>Impact:<p>pSMA is a reliable measure of muscle and muscle loss and should be considered in future studies assessing muscle loss in patients with PDAC.</p></div>

Authors

Publication Details

Published
2025-09-02
DOI
https://doi.org/10.1158/1055-9965.c.8011973
Primary Topic
Body Contouring and Surgery
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Data from The Impact of Edema on Skeletal Muscle Changes among Patients with Pancreatic Ductal Adenocarcinoma

Dung‐Tsa Chen, Elena M. Cortizas, Shaffer Mok, John M. Koomen et al.
1 links
Body Contouring and Surgery
article

Data from The Impact of Edema on Skeletal Muscle Changes among Patients with Pancreatic Ductal Adenocarcinoma

Dung‐Tsa Chen, Elena M. Cortizas, Shaffer Mok, John M. Koomen, Daniel Jeong, Mokenge P. Malafa, Kun Jiang, Wade G. Douglas, Toni L. Basinski, Sabeen Ahmed, Aleksandra Karolak, Lauren Marie Sparks, Jennifer B. Permuth, Jason B. Fleming, Tiffany L. Carson, Maria Genilo-Delgado, Vic Velanovich, Ghulam Rasool, Jamie K. Teer, José G. Treviño, Tiago Biachi De Castria, Sylvia L. Crowder, Andrew R. Judge, J. Pablo Arnoletti, Nathan H. Parker, Qianxing Mo, Alexandra F. Tassielli, Evan W. Davis, Sarah M. Judge, Kevin L. Huguet, Christopher J. Whelan, Mark Bloomston, Margaret A. Park, Paul A. Stewart, José M. Pimiento, Xuefeng Wang, Lina Moreno-Urazan, Anjana A. Menon, Dae Won Kim, Pamela J. Hodul, Manuel A. Molina-Vega
article en

Abstract

<div>AbstractBackground:<p>Muscle loss influences pancreatic ductal adenocarcinoma (PDAC) outcomes, but treatment-related edema may cause overestimation of total skeletal muscle area (tSMA), confounding our understanding of muscle changes. However, no studies have quantified the impact of edema on tSMA and psoas skeletal muscle area (pSMA) changes. Thus, we sought to (i) assess the impact of edema on tSMA and pSMA changes between diagnosis and follow-up and (ii) explore the utility of pSMA as a clinically relevant measure of muscle and muscle loss among patients with PDAC.</p>Methods:<p>Body composition was measured using CT scans at diagnosis and follow-up from 95 patients enrolled in the Florida Pancreas Collaborative cohort study. Edema was assessed by opacifications in subcutaneous fat, and tSMA and pSMA changes were expressed as percent change between diagnosis and follow-up. We used multivariable generalized linear models to estimate mean tSMA and pSMA changes overall and by edema status. Spearman correlation was used to measure interrelationships of tSMA and pSMA.</p>Results:<p>tSMA increased between diagnosis and follow-up (Δ = 0.66) but only in patients with edema (Δ = 3.35) whereas non-edematous patients lost tSMA (Δ = −2.03). Conversely, pSMA decreased regardless of edema status. Furthermore, tSMA and pSMA were strongly correlated overall (<i>r</i> = 0.75) and in non-edematous patients (<i>r</i> = 0.83).</p>Conclusions:<p>Edema inflated estimates of tSMA at follow-up in patients with PDAC, but pSMA was impervious to edema and may represent a suitable proxy for tSMA.</p>Impact:<p>pSMA is a reliable measure of muscle and muscle loss and should be considered in future studies assessing muscle loss in patients with PDAC.</p></div>

Openalex Percentile: Top 63%
Body Contouring and Surgery
DOIOpen Access PDFOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.