Crispr-Cas Systems in Crop Improvement: A Chemistry-Genetics Interface for Precision Agriculture
This research delved into the possibilities of polyherbal nanoparticle concoctions for the management of diabetes, emphasising the enhancement of bioavailability and therapeutic effectiveness of herbal constituents. Our research indicates that the synergy of Bitter melon, Cinnamon, and Ginseng, when delivered through nanocarriers like liposomes, solid lipid nanoparticles, and polymeric nanoparticles, markedly improved the therapeutic outcomes, particularly in regulating blood glucose levels in rats with Type 2 diabetes. The nanoparticles exhibited a regulated and extended liberation of bioactive substances, providing enduring therapeutic benefits in contrast to unbound herbal extracts. This holds particular significance in the realm of diabetes management, where maintaining consistent blood glucose levels over time is vital. Furthermore, the research validated the safety of these formulations, revealing no notable effects on liver or kidney performance, suggesting that polyherbal nanoparticle formulations may present a practical and safer option compared to traditional diabetes therapies. This groundbreaking method of merging nanotechnology with herbal remedies presents an encouraging tactic for managing diabetes and may significantly diminish the adverse effects linked to traditional synthetic medications.
Authors
- Gopa Mishra (ORCID: https://orcid.org/0009-0003-7666-2975)
- Lipsa Prit Bhusan
- Akshay Kumar Vats (ORCID: https://orcid.org/0000-0003-0168-0776)
- Shikha Jain
- Debashish Hota (ORCID: https://orcid.org/0000-0002-2584-8337)
- Shubham Singh (ORCID: https://orcid.org/0000-0001-5549-9919)
- Diksha Sinha (ORCID: https://orcid.org/0000-0002-5058-8012)
- Sangeeta Jain (ORCID: https://orcid.org/0000-0002-9660-2908)
Institutions
- Acharya N. G. Ranga Agricultural University (IN)
- Siksha O Anusandhan University (IN)
- Jharkhand Rai University (IN)
- U.S. Horticultural Research Laboratory (US)
- Dr. Hari Singh Gour University (IN)
Publication Details
- Journal
- Oriental Journal Of Chemistry
- Published
- 2025-08-31
- DOI
- https://doi.org/10.13005/ojc/410437
- Primary Topic
- CRISPR and Genetic Engineering
- Type
- article
- Field-Weighted Citation Impact
- 0.00