Exploring the Causal Links Between 338 Cerebrospinal Fluid Metabolites and Parkinson's Disease
This analysis of MR reveals multiple CSF metabolites that have causal links to PD. Increased levels of glycerophosphoinositol and oxalate are associated with higher risk, whereas caffeine provide protective benefits. These metabolites may act as potential biomarkers and treatment targets for PD.
Authors
- Houwen Zhang (ORCID: https://orcid.org/0000-0002-8675-3518)
- You Wu (ORCID: https://orcid.org/0009-0000-9779-0309)
- Fangzheng Cao (ORCID: https://orcid.org/0009-0004-1226-0683)
- Chunrong Li (ORCID: https://orcid.org/0000-0002-8803-7232)
- Yu Liang (ORCID: https://orcid.org/0009-0003-3436-7310)
- Jialin Yu (ORCID: https://orcid.org/0000-0002-5209-0701)
Institutions
- Zhejiang Chinese Medical University (CN)
- Zhejiang Provincial People's Hospital (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Hangzhou Medical College (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/brb3.70815
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Young Scientists Fund