Neutrophils in ANCA-associated vasculitis: The role in the pathogenesis and promising therapeutic strategies
The review focuses on the latest data on the role of neutrophils in the pathogenesis of ANCA-associated systemic vasculitis (AAV). Numerous signaling pathways for the regulation of neutrophil function during AAV development are discussed, including the role of neutrophil proteases, neutrophil extracellular traps, the influence of complement components and intercellular interactions. The impact of extracorporeal treatments is discussed. The perspective goals of therapy are considered.
Authors
- А. М. Лила (ORCID: https://orcid.org/0000-0002-6068-3080)
- Е. Л. Насонов (ORCID: https://orcid.org/0000-0002-1598-8360)
- А. А. Соколов (ORCID: https://orcid.org/0000-0001-7004-0903)
- Т. V. Beketova (ORCID: https://orcid.org/0000-0003-2641-9785)
- I. Yu. Popov (ORCID: https://orcid.org/0000-0002-6373-332X)
Institutions
- Central State Medical Academy (RU)
- Russian Medical Academy of Continuous Professional Education (RU)
- North-Western State Medical University named after I.I. Mechnikov (RU)
Publication Details
- Journal
- Rheumatology Science and Practice
- Published
- 2025-08-31
- DOI
- https://doi.org/10.47360/1995-4484-2025-338-347
- Primary Topic
- Vasculitis and related conditions
- Type
- article
- Field-Weighted Citation Impact
- 0.00