Synthesis, Spectral Characterization, and Molecular Docking of Novel Schiff Bases with Potential Lung Cancer Activity

In this study, eight important compounds of new Schiff bases linked to tetrazoles and triazoles were synthesized, which may have importance in cancer treatment according to the molecular docking study conducted in this paper by the reaction of tetrazole acid with thiocarbohydrazide to produce an amino triazole thione compound, which was subsequently reacted with eight aromatic aldehyde derivatives. Tetrazole acid was prepared from the reaction of 4-aminobenzoic acid with sodium azide and trimethyl orthoformate with the existence of acetic acid. Thiocarbohydrazide was prepared by the drop wise addition of carbon disulfide to hydrazine hydrate. All synthesized compounds, their structure where confirmed by spectral ( FT-IR,1HNMR ) data. Matrix metalloproteinases (MMPs) play a critical role in cancer progression by degrading the extracellular matrix (ECM), thereby facilitating tumor cell invasion and metastasis. Additionally, MMPs contribute to tumor angiogenesis by promoting the formation of new blood vessels that sustain tumor growth. Therefore, inhibition of MMPs represents a promising therapeutic strategy in cancer treatment, as it may reduce tumor spread and enhance the efficacy of other anticancer therapies. Therefore, molecular docking studies against MMPs protein receptors showed strong binding affinities (ΔG values up to -6.4 kcal/mol), indicating promising anticancer potential.