Figure S5 from CRISPR Screens Identify POLB as a Synthetic Lethal Enhancer of PARP Inhibition Exclusively in BRCA-Mutated Tumors
<p>Supplementary Figure S5. Body weight of the animals is not impacted by the treatment with niraparib – related to Figure 6. A) Effect on body weights of animals containing MDA-MB-436 sgIntron or sgPOLB xenografts treated with vehicle and niraparib at 15 mpk once daily for 28 days. Data is represented as % change in body weights until day 28. B) Effect on body weights of animals containing DLD-1 BRCA2 null sgIntron or sgPOLB xenografts treated with vehicle and niraparib at 30 mpk (left) and 60 mpk (right) once daily for 20 days. Data is represented as % change in body weights until day 20.</p>
Authors
- Brian Doyon
- Madhavi Bandi (ORCID: https://orcid.org/0000-0002-7562-0170)
- Tianshu Feng (ORCID: https://orcid.org/0000-0002-9445-4876)
- William D. Mallender
- Robert Tjin Tham Sjin (ORCID: https://orcid.org/0000-0002-3809-8424)
- Jannik N. Andersen (ORCID: https://orcid.org/0000-0003-4528-2120)
- Erik Wilker (ORCID: https://orcid.org/0000-0003-4535-178X)
- Douglas A. Whittington (ORCID: https://orcid.org/0000-0002-5946-8543)
- Alan Huang (ORCID: https://orcid.org/0000-0001-5501-0212)
- Yi Yu (ORCID: https://orcid.org/0000-0002-2223-337X)
- Xuewen Pan (ORCID: https://orcid.org/0000-0002-0148-5631)
- Katherine Lazarides (ORCID: https://orcid.org/0000-0002-0878-0465)
- Shangtao Liu (ORCID: https://orcid.org/0000-0002-2724-9178)
- Hongxiang Zhang (ORCID: https://orcid.org/0000-0001-6794-0038)
- Ashley H. Choi (ORCID: https://orcid.org/0000-0002-2802-7163)
- Justin L. Engel (ORCID: https://orcid.org/0000-0002-2016-3494)
- Binzhang Shen (ORCID: https://orcid.org/0000-0002-6556-7791)
- Samuel R. Meier (ORCID: https://orcid.org/0000-0002-7026-2722)
- Brian J. McMillan (ORCID: https://orcid.org/0000-0002-3134-7774)
- Michele Meseonznik
Publication Details
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1158/1535-7163.30028928
- Primary Topic
- PARP inhibition in cancer therapy
- Type
- article
- Field-Weighted Citation Impact
- 0.00