Amentoflavone as a dual-target inhibitor of IL11 signaling alleviates intervertebral disc fibrosis
IL11 plays a pivotal role in the fibrotic remodeling of NP cells during IVDD. Amentoflavone suppresses IL11-driven fibrosis by targeting both IL11RA and IL6ST, offering a promising therapeutic strategy for IVDD.
Authors
- Boxuan Xu (ORCID: https://orcid.org/0009-0003-4232-6682)
- Min Su (ORCID: https://orcid.org/0000-0003-3589-9573)
- Yiping Chen
- Zhibin Chen (ORCID: https://orcid.org/0000-0002-2865-8416)
- Rongsheng Chen (ORCID: https://orcid.org/0000-0002-1208-9458)
- Weihong Xu
Institutions
- Fujian Medical University (CN)
- First Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- International Immunopharmacology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1016/j.intimp.2025.115450
- Citations
- 1
- Primary Topic
- Spine and Intervertebral Disc Pathology
- Type
- article
- Field-Weighted Citation Impact
- 1.47