Instrumental variable approaches for estimating time-varying treatment effects in comparative effectiveness research
The proposed IV-based g-estimation approach can be reliably used in the estimation of time-varying treatments if a valid time-varying IV is available. The weighting approach offers an accessible alternative but was found to work well only when the IVs are strongly associated with treatment assignment, which is relatively unlikely in real-world applications.
Authors
- Manuel Gomes (ORCID: https://orcid.org/0000-0002-1428-1232)
- R. A. F. Grieve (ORCID: https://orcid.org/0000-0002-0000-5771)
- Stijn Vansteelandt (ORCID: https://orcid.org/0000-0002-4207-8733)
- William G Dixon
- Daniel Tompsett (ORCID: https://orcid.org/0000-0001-6761-6270)
Institutions
- HOGENT University of Applied Sciences and Arts (BE)
- University of Manchester (GB)
- Ghent University (BE)
- London School of Hygiene & Tropical Medicine (GB)
- University College London (GB)
Publication Details
- Journal
- BMC Medical Research Methodology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s12874-025-02625-y
- Primary Topic
- Advanced Causal Inference Techniques
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Medical Research Council