Allogeneic Bone Marrow‐Derived Mesenchymal Stem Cells for Parkinson's Disease: A Randomized Trial
Three infusions of 10 × 10<sup>6</sup> allo-hMSCs/kg improved motor function in mild-to-moderate PwP, while two infusions showed less improvement than placebo. To address this discrepancy, future studies should conduct functional potency assays to understand batch-to-batch variability affecting clinical efficacy. © 2025 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.
Authors
- Jerome G. Saltarrelli (ORCID: https://orcid.org/0000-0002-3378-7669)
- Timothy M. Ellmore (ORCID: https://orcid.org/0000-0001-6125-0044)
- Nikunj Satani (ORCID: https://orcid.org/0000-0003-3908-3731)
- Shahnawaz Mohammad (ORCID: https://orcid.org/0000-0003-2782-4002)
- Sean I. Savitz (ORCID: https://orcid.org/0000-0003-4637-1790)
- Elsa M. Rodarte (ORCID: https://orcid.org/0000-0001-7138-0790)
- Mya C. Schiess (ORCID: https://orcid.org/0000-0001-9348-2587)
- Juan De Luigi Lemus (ORCID: https://orcid.org/0000-0002-3042-7633)
- Emily Tharp (ORCID: https://orcid.org/0009-0006-7371-8680)
- T Thomas
- Charles E. Green (ORCID: https://orcid.org/0000-0001-9192-8215)
- Jessika Suescun (ORCID: https://orcid.org/0000-0003-3936-3936)
- Christopher Adams (ORCID: https://orcid.org/0000-0001-8847-2501)
- Marie Françoise Doursout (ORCID: https://orcid.org/0000-0003-0859-7051)
- Vanessa Thyne
- Rula Abuamouneh
Institutions
- City College of New York (US)
- University of Washington (US)
- Centre for Movement Disorders (CA)
- The University of Texas Health Science Center (US)
Publication Details
- Journal
- Movement Disorders
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/mds.70028
- Citations
- 3
- Primary Topic
- Mesenchymal stem cell research
- Type
- article
- Field-Weighted Citation Impact
- 4.88
Funders
- Michael J. Fox Foundation for Parkinson's Research
- University of Texas Health Science Center at Houston