Immune-mediated bone loss: A Mendelian randomization and NHANES-based study of viral infections and osteoporosis
Our findings suggest that common herpesvirus infections may contribute to bone loss via immune-mediated mechanisms, especially in vulnerable subgroups. These results provide epidemiological support for a viral-immune link in osteoporosis and underscore the need for mechanistic and longitudinal studies to clarify underlying pathways and guide future preventive strategies.
Authors
- Lingting Wang
- Yuesheng Wang (ORCID: https://orcid.org/0000-0001-7269-9015)
- Ying He (ORCID: https://orcid.org/0000-0003-2023-5547)
- Li Xiong (ORCID: https://orcid.org/0000-0003-3851-937X)
- He Liu (ORCID: https://orcid.org/0000-0001-9177-9459)
- Fan Bai
Institutions
- Wannan Medical College (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Virus Research
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.virusres.2025.199627
- Primary Topic
- Genetic factors in colorectal cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Wannan Medical College