Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach

T2-targeting biologics have utility in the management of asthma with low T2 involvement, but more effective therapies are needed. Further research is warranted to identify specific pathogenic pathways at the lower end of the T2 spectrum that can be effectively targeted by biologics.

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Publication Details

Journal
The Journal of Allergy and Clinical Immunology In Practice
Published
2025-09-02
DOI
https://doi.org/10.1016/j.jaip.2025.08.021
Citations
1
Primary Topic
Asthma and respiratory diseases
Type
article
Field-Weighted Citation Impact
1.16

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article

Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach

Lakmini Bulathsinhala, Piotr Kuna, Matthew Peters, Guy Brusselle et al.
1 citations
The Journal of Allergy and Clinical Immunology In Practice
Asthma and respiratory diseases
1.16
article

Response to Biologics Along a Gradient of T2 Involvement in Patients With Severe Asthma: A Data-Driven Biomarker Clustering Approach

Lakmini Bulathsinhala, Piotr Kuna, Matthew Peters, Guy Brusselle, Riyad Al‐Lehebi, Camille Taillé, Tatsuya Nagano, Andriana Ι. Papaioannou, Liam Gabriel Heaney, Dóra Lúðvíksdóttir, Neil A. Martin, Ruth Murray, Njira Lucia Lugogo, Sinthia Bosnic‐Anticevich, Chau‐Chyun Sheu, James Fingleton, Andrew Menzies‐Gow, Mohsen Sadatsafavi, Giulia Scioscia, Trung N. Tran, Sundeep Salvi, Jorge Fernando Maspero, Flavia Hoyte, Giorgio Walter Canonica, Richard W. Costello, Chin Kook Rhee, John Busby, Michael E. Wechsler, Kenneth R. Chapman, George Christoff, Désirée Larenas‐Linnemann, Peter G. Gibson, Todor A. Popov, Christian Taube, Francesca Puggioni, Nicholas Chapman, Alan Altraja, William Henley, Eileen Wang, Sverre Lehmann, А. S. Belevskiy, Leif Hilding Bjermer, David Price, Susanne Hansen, Alf Tunsäter, Paul Pfeffer, Céline Bergeron, Shawn David Aaron, Richard Hubbard, Κonstantinos Κostikas, Victoria Carter, Borja G. Cosío, Unnur Steina Björnsdóttir, Mona Al‐Ahmad, Anna Quinton, Carlos A. Torres‐Duque, Rohit Katial, Paulo Márcio Pitrez, Enrico Marco Heffler, Ming‐Ju Tsai, Luis Pérez de Llano, Concetta Sirena, Celeste Porsbjerg, Takashi Iwanaga, João Fonseca, Lauri Lehtimäki, Roy A. Pleasants, Mark Hew, Aaron Beastall, Nikolaos G. Papadopoulos, Pujan H. Patel, David J. Jackson, Arjun Mohan, Bassam Mahboub, Arnaud Bourdin, Mina Gaga, Diahn‐Warng Perng, Takahiko Horiguchi, Peter Barker, Mariko Siyue Koh, Renaud Louis, Charlotte Suppli Ulrik
article en
1 citations

Abstract

T2-targeting biologics have utility in the management of asthma with low T2 involvement, but more effective therapies are needed. Further research is warranted to identify specific pathogenic pathways at the lower end of the T2 spectrum that can be effectively targeted by biologics.

The Journal of Allergy and Clinical Immunology In PracticeVol. 13(12)
AstraZeneca (United Kingdom) (GB), University of Foggia (IT), Reykjavík University (IS), Queen's University Belfast (GB), Dubai Health Authority (AE), Toyota Motor Corporation (Switzerland) (CH), Centre National de la Recherche Scientifique (FR), New South Wales Department of Health (AU), National Institute of Technology, Toyota College (JP), Humanitas University (IT), Alfaisal University (SA), University of British Columbia (CA), Kaohsiung Medical University (TW), University of Leicester (GB), Inserm (FR), University of Liège (BE), University of Iceland (IS), Queen Mary University of London (GB), Délégation Paris 7 (FR), King's College London (GB), University of Toronto (CA), Lund University (SE), University of Ioannina (GR), Université de Montpellier (FR), National and Kapodistrian University of Athens (GR), Université Paris Cité (FR), Singapore General Hospital (SG), Barts Health NHS Trust (GB), Bulgarian Academy of Sciences (BG), University of Michigan (US), Vancouver Hospital and Health Sciences Centre (CA), Concord Repatriation General Hospital (AU), John Hunter Hospital (AU), Santa Casa Hospital (BR), Ottawa Hospital (CA), Haukeland University Hospital (NO), Woolcock Institute of Medical Research (AU), Frederiksberg Hospital (DK), Ghent University Hospital (BE), Beaumont Hospital (IE), King Fahd Medical City (SA), Bispebjerg Hospital (DK), Erasmus MC (NL), Tartu University Hospital (EE), Copenhagen University Hospital (DK), Harefield Hospital (GB), Vancouver General Hospital (CA), Taipei Veterans General Hospital (TW), National Jewish Health (US), Pirogov Russian National Research Medical University (RU), Kuwait University (KW), Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR), Hunter Medical Research Institute (AU), Ruhrlandklinik (DE), Kindai University Hospital (JP), Royal Brompton Hospital (GB), Assistance Publique – Hôpitaux de Paris (FR), Lung Institute (US), Hospital Médica Sur (MX), University Hospital St. Ivan Rilski (BG), National University Hospital of Iceland (IS), AstraZeneca (France) (FR), Observational & Pragmatic Research Institute (SG), Fundación Neumológica Colombiana (CO), Monash Health (AU), Hygeia Hospital (GR), Medical University of Lodz (PL), Capital and Coast District Health Board (NZ), Health Research Institute of the Balearic Islands (ES), Tampere University Hospital (FI), Ministry of Health (KW), Tampere University (FI), Centre for Health Technology and Services Research (PT), Skåne University Hospital (SE), AstraZeneca (Italy) (IT), Hospital Universitario Lucus Augusti (ES), Hôpital Bichat-Claude-Bernard (FR), AstraZeneca (United States) (US), Hospital Universitario Son Espases (ES), Favaloro Foundation (AR), The Catholic University of Korea Seoul St. Mary's Hospital (KR), IRCCS Humanitas Research Hospital (IT), Alfred Health (AU), Ottawa Hospital Research Institute (CA), University of Tartu (EE), Kobe University (JP), Athens State University (US), Jewish Hospital (US), Catholic University of Korea (KR), University of Colorado Denver (US), Macquarie University (AU)
Amgen, Bristol-Myers Squibb, Pfizer, AstraZeneca, GlaxoSmithKline, Sanofi, Gilead Sciences, Teva Pharmaceutical Industries, United Therapeutics Corporation, Regeneron Pharmaceuticals, Optimum Patient Care, Horizon Therapeutics, Glenmark Pharmaceuticals, Insmed, Singapore General Hospital, Shionogi, Grifols, Genentech, Daiichi Sankyo Europe
Openalex Percentile: Top 18%
Asthma and respiratory diseases
1.16
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