From fat to flame: Multi-omic insights into how adipose-joint crosstalk stokes the fires of osteoarthritis
Our findings demonstrate that joint adipose tissues contribute to inflammatory and metabolic dysfunction in OA joints. These interactions offer insight into disease pathophysiology and may help identify candidate therapeutic targets, although further in vivo studies are needed to confirm their functional relevance.
Authors
- Thomas Nicholson (ORCID: https://orcid.org/0000-0001-5826-7312)
- Edward T. Davis (ORCID: https://orcid.org/0000-0003-2198-9068)
- Jon Hazeldine (ORCID: https://orcid.org/0000-0002-4280-4889)
- Susanne N. Wijesinghe (ORCID: https://orcid.org/0000-0001-7981-8216)
- Michael MacLeod (ORCID: https://orcid.org/0000-0003-2444-6886)
- Simon W. Jones (ORCID: https://orcid.org/0000-0001-6785-2310)
- Ellie Northall (ORCID: https://orcid.org/0000-0003-4694-2071)
- Michael Sagmeister (ORCID: https://orcid.org/0000-0002-6166-6784)
- Caitlin Ditchfield (ORCID: https://orcid.org/0009-0008-0508-2646)
Institutions
- University of Birmingham (GB)
Publication Details
- Journal
- Osteoarthritis and Cartilage
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1016/j.joca.2025.08.012
- Citations
- 3
- Primary Topic
- Fibromyalgia and Chronic Fatigue Syndrome Research
- Type
- article
- Field-Weighted Citation Impact
- 4.41
Funders
- UK Research and Innovation
- Versus Arthritis
- Medical Research Council