Optimizing Nanowire Dimensions for Enhanced Performance in Biosensing Platforms for Early Detection of Dengue

Because of their exceptional mechanical, optical, and electrical characteristics, Nanowires (NWs) have become important parts of biosensing platforms. Early identification is the key to containing epidemics and lowering morbidity caused by the Dengue Virus (DENV). The label-free, real-time detection capabilities of biosensors based on Nanowires (NW) are made possible by their programmable electrical characteristics and huge surface-to-volume ratios. In this study, we look at how the length and width of nanowires affect the effectiveness of biosensors designed to detect the dengue virus NS1 antigen early on. Using a combination of simulation and experimental validation, we identify the optimal NW configuration that maximizes sensitivity, lowers the Limit of Detection (LOD), and ensures practical integration for point-of-care diagnostics.