The tryptophan catabolite pathway in major and simple neurocognitive psychosis: a double-edged sword with two sharpened edges
The alterations in serum TRYCAT levels further emphasize that MNP and SNP represent two biologically distinct subtypes of schizophrenia. The reductions in TRYCATs diminish the antioxidant and immunoregulatory functions of the TRYCAT pathway. Elevated QA levels may exacerbate the disruption of the blood-brain barrier and the immune-related and oxidative neurotoxicity in MNP.
Authors
- Ameer Abdul Razzaq Al-Issa
- Michael H. J. Maes (ORCID: https://orcid.org/0000-0002-2012-871X)
- Hussein Kadhem Al‐Hakeim (ORCID: https://orcid.org/0000-0001-6143-5196)
- Chen Chen (ORCID: https://orcid.org/0000-0003-2541-6283)
Institutions
- Academy of Medical Sciences (GB)
- University of Electronic Science and Technology of China (CN)
- Chulalongkorn University (TH)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Medical University Plovdiv (BG)
- Kyung Hee University (KR)
- University of Kufa (IQ)
Publication Details
- Journal
- Acta Neuropsychiatrica
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1017/neu.2025.5
- Citations
- 1
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.58
Funders
- University of Cambridge