Sentrin/SUMO-specific protease 1 contributes to drug resistance in melanoma by mediating the deSUMOylation of Yes-associated protein
This study suggests that there is a positive correlation between the ubiquitin-specific protease SENP1 and drug resistance in melanoma. Its up-regulation may lead to changes in the deSUMOylation of YAP, activate the Hippo signalling pathway, and increase the resistance of melanoma to DTIC.
Authors
- Bei Zhao (ORCID: https://orcid.org/0009-0009-9453-0427)
- Xuemei Tang (ORCID: https://orcid.org/0000-0003-0957-6420)
- Shi Cheng (ORCID: https://orcid.org/0000-0002-2631-3262)
- Yinghua Liu
Institutions
- University of Electronic Science and Technology of China (CN)
Publication Details
- Journal
- Advances in Dermatology and Allergology
- Published
- 2025-01-01
- DOI
- https://doi.org/10.5114/ada.2025.153499
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00