CSF Mitochondrial DNA: Biomarker of Body Composition and Energy Metabolism in Parkinson's Disease
CSF cf-mtDNA levels are reduced in PD and influenced by body composition and nutritional status, supporting their role as a metabolic biomarker. While the cf-mtDNA deletion ratio remained unchanged, its association with body composition suggests a complex interplay between mitochondrial integrity and metabolism. These findings highlight the relevance of cf-mtDNA in PD pathophysiology and the need for further study.
Authors
- Ryunosuke Nagao (ORCID: https://orcid.org/0009-0001-4412-3892)
- Hirohisa Watanabe (ORCID: https://orcid.org/0000-0001-8553-8536)
- Reiko Ohdake (ORCID: https://orcid.org/0000-0001-8282-9434)
- Atsuhiro Higashi (ORCID: https://orcid.org/0009-0008-7408-9710)
- Mizuki Ito (ORCID: https://orcid.org/0000-0003-4470-1004)
- Sayuri Shima (ORCID: https://orcid.org/0000-0003-1761-0123)
- Yasuhiro Maeda (ORCID: https://orcid.org/0000-0001-8327-5875)
- Yasuaki Mizutani (ORCID: https://orcid.org/0000-0002-5709-8526)
- Kazuya Kawabata (ORCID: https://orcid.org/0000-0002-8851-4377)
- Toshiki Maeda (ORCID: https://orcid.org/0000-0002-5634-9792)
- Akihiro Ueda (ORCID: https://orcid.org/0000-0002-9636-3011)
- T. NAKAI
Institutions
- Fujita Health University (JP)
Publication Details
- Journal
- Annals of Clinical and Translational Neurology
- Published
- 2025-09-01
- DOI
- https://doi.org/10.1002/acn3.70183
- Primary Topic
- Parkinson's Disease Mechanisms and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Japan Society for the Promotion of Science