Malignant epithelia cells-derived spermine induces APOE+ macrophages to suppress tumor immunity in adenocarcinoma of the esophagogastric junction
This study identified AEG-like malignant cells as a high-risk subtype, revealed the metabolic-immune crosstalk driven by the spermine-STAT3-APOE axis in AEG progression, and provided potential targets for AEG metabolic intervention and immunotherapy.
Authors
- Zhenxiang Wang (ORCID: https://orcid.org/0000-0002-2518-1528)
- Yanping Xu (ORCID: https://orcid.org/0000-0002-6133-8676)
- Zhiqian Hu (ORCID: https://orcid.org/0000-0002-3973-6280)
- Chenfei Wang (ORCID: https://orcid.org/0000-0001-7573-3768)
- Shuchang Xu (ORCID: https://orcid.org/0000-0002-4742-2759)
- Ye Chen (ORCID: https://orcid.org/0000-0001-5317-4846)
- Ying Chen (ORCID: https://orcid.org/0000-0002-5105-5402)
- Yan Zhang (ORCID: https://orcid.org/0000-0002-2947-1629)
- Zhaoyang Liu (ORCID: https://orcid.org/0000-0003-0124-0113)
- Kai Xu (ORCID: https://orcid.org/0000-0001-6611-3516)
- Xinxing Li (ORCID: https://orcid.org/0000-0003-1129-0085)
- Huihui Sun (ORCID: https://orcid.org/0000-0002-6976-0046)
Institutions
- Tongji University (CN)
- Tongji Hospital (CN)
Publication Details
- Journal
- Frontiers in Medicine
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fmed.2025.1636699
- Citations
- 1
- Primary Topic
- Cancer Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.23
Funders
- National Natural Science Foundation of China
- Tongji University
- Shanghai Municipal Commission of Economy and Informatization
- Fundamental Research Funds for the Central Universities