Depletion of Mycobacterium tuberculosis transmembrane protein Rv3737 reduces pathogen survival and induces M1 macrophage polarization against tuberculosis
Rv3737 suppresses M1 macrophage polarization to promote Mtb survival. Its deletion enhances host antimicrobial activity by activating NF-κB and MAPK signaling pathways. Targeting Rv3737 may represent a novel strategy for tuberculosis therapy.
Authors
- Renzhong He
- Chang Shu (ORCID: https://orcid.org/0000-0002-0995-3903)
- Tao You (ORCID: https://orcid.org/0000-0002-1338-6630)
- Qing Yun Li (ORCID: https://orcid.org/0000-0001-8128-6319)
- Ling Chen (ORCID: https://orcid.org/0000-0003-1485-1626)
- Nana Li (ORCID: https://orcid.org/0000-0002-9740-0558)
- Chao Xu
- Lin Xu (ORCID: https://orcid.org/0000-0003-1345-5189)
- Zhangli Peng
Institutions
- Zunyi Medical University (CN)
- Affiliated Hospital of Zunyi Medical College (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fcimb.2025.1592296
- Citations
- 2
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 2.79