Gut microbiota and its metabolites promote painful diabetic peripheral neuropathy complicated with cognitive dysfunction in mice
This study highlights the intricate relationship between gut microbiota, metabolites, and both PDPN and cognitive dysfunction in <i>db</i>/<i>db</i> mice. It also provides insights into potential mechanisms underlying the pathophysiology of these comorbidities, suggesting that modulation of the gut microbiota and its metabolites may offer new therapeutic strategies.
Authors
- Ya Xu (ORCID: https://orcid.org/0000-0001-9360-8848)
- Xueli Yang (ORCID: https://orcid.org/0000-0002-8373-4389)
- Junpeng Yang (ORCID: https://orcid.org/0000-0003-0902-1716)
- Fenglian Huang (ORCID: https://orcid.org/0009-0005-5603-938X)
- Chenghong Liang (ORCID: https://orcid.org/0000-0002-2239-742X)
- Xinru Deng (ORCID: https://orcid.org/0000-0003-3747-9310)
- Shasha Tang (ORCID: https://orcid.org/0000-0002-1307-3124)
- Huijuan Yuan (ORCID: https://orcid.org/0000-0002-0486-0994)
- Xin Lv (ORCID: https://orcid.org/0000-0001-7033-7328)
- Yalei Liu (ORCID: https://orcid.org/0009-0000-2598-9845)
- Limin Wang
- Xiaobing Wang (ORCID: https://orcid.org/0000-0002-0907-364X)
- Lingyun Zhao (ORCID: https://orcid.org/0000-0002-7055-2746)
- Danyu Wang (ORCID: https://orcid.org/0000-0002-3127-5328)
- Yuanyuan Fang (ORCID: https://orcid.org/0000-0002-1313-1259)
- Xiaoyang Shi
Institutions
- Henan Provincial People's Hospital (CN)
Publication Details
- Journal
- Frontiers in Cellular and Infection Microbiology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fcimb.2025.1599954
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 0.00