Synthesis and Biological activities of New Pyrazoline Incorporated Pyridine-Triazole Derivatives

The potential of pyridine, triazole and pyrazoline scaffolds as anticancer, anticonvulsant, antidiabetic, antioxidant, analgesic, antibacterial, neuroprotective, etc. makes them essential intermediates for new drug discovery. Framing pyrazoline scaffolds with triazole and pyridine is a novel approach to design effective drugs. We have prepared a series of pyrazoline incorporated pyridine-triazole ( 6a-o) from Isoiniazid. FT-IR, 1H NMR, 13C NMR, and LCMS spectra were used to describe all produced compounds. The antibacterial and radial scavenging screening were carried out through disc diffusion and DPPH, respectively.