Variable expression of hepatic genes in different liver tumor cell lines: conclusions for drug testing
Our findings emphasize the importance of careful selection and validation of <i>in vitro</i> models in hepatotoxicity testing, as significant differences exist in their gene expression profiles and functional characteristics.
Authors
- Joanna Motyl (ORCID: https://orcid.org/0000-0002-4170-9732)
- Monika Wiśniewska
- Dorota G. Pijanowska (ORCID: https://orcid.org/0000-0001-8431-8910)
- Beata Burzyńska (ORCID: https://orcid.org/0000-0003-1595-0036)
- Agnieszka Wencel (ORCID: https://orcid.org/0000-0003-4582-8250)
- Malgorzata Jakubowska (ORCID: https://orcid.org/0009-0005-8684-2042)
- Krzysztof Dudek (ORCID: https://orcid.org/0000-0002-9442-989X)
- Krzysztof Dariusz Pluta (ORCID: https://orcid.org/0000-0003-1706-2788)
Institutions
- Medical University of Warsaw (PL)
- Institute of Biochemistry and Biophysics, Polish Academy of Sciences (PL)
- Institute of Biocybernetics and Biomedical Engineering (PL)
- Polish Academy of Sciences (PL)
Publication Details
- Journal
- Frontiers in Cell and Developmental Biology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fcell.2025.1646602
- Citations
- 3
- Primary Topic
- Pharmacogenetics and Drug Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 4.67