Stability Indicating Spectrofluorimetric Method for the Estimation of Escitalopram in Bulk and Pharmaceutical Dosage Form

Aim: The purpose of this research was to design and validate a reliable, sensitive, and accurate spectrofluorimetric approach for the determination of Escitalopram. Materials and Methods: Acetonitrile was used as the solvent, and the λmax was determined to be 239 nm. The technique has been applicable for accuracy, limit of detection (LOD), linearity, limit of quantification (LOQ), as well as precision. Results: On the basis of the results, escitalopram had a correlation coefficient of 0.9992 as well as was linear in 1–9µg/mL range. Value of LOD had been 0.112µg/mL, whereas LOQ had been 0.370µg/mL. Stability studies demonstrated that Escitalopram was vulnerable to alkaline, acid, along with oxidative degradation. Conclusion: The developed spectrofluorimetric method has been discovered to be sensitive, simple, and appropriate for Escitalopram quantification. The method met the ICH guidelines for linearity, precision, LOD, accuracy, and LOQ, making it suitable for regular quality inspection of Active Pharmaceutical Ingredient (API) and formulations.