The histone acetylation-related gene signature predicts prognosis and immunotherapy response in stomach adenocarcinoma
A novel histone acetylation-related gene signature, which possesses potential value in predicting the prognosis and immunotherapy effectiveness regarding STAD patients, was developed. This signature may serve as a reliable biomarker for prognosis of STAD and promote the identification of novel treatment targets for STAD. Furthermore, DCLK1 exhibited oncogenic roles and may be a new target for STAD therapy.
Authors
- Changhua Zhang (ORCID: https://orcid.org/0000-0002-0974-3455)
- Guangyao Liu (ORCID: https://orcid.org/0000-0001-8598-0762)
- Chen Dai (ORCID: https://orcid.org/0000-0001-5911-3489)
- Rishun Su
- Zhenzhen Zhao
- Wenbin Hou
- Yulong He (ORCID: https://orcid.org/0000-0001-8930-8404)
- Songcheng Yin
- Yangyang Guo
Institutions
- Wannan Medical College (CN)
- Sun Yat-sen University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Wenzhou Medical University (CN)
- The Seventh Affiliated Hospital of Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fonc.2025.1527253
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00