Gut microbiome modulation by Weifuchun Capsules alleviates chronic atrophic gastritis: a combined microbiota and metabolomics approach
Our findings highlight that modulation of gut microbiota composition is central to the therapeutic effects of WFC on CAG. WFC exerts its gastroprotective activity primarily by reshaping specific gut microbial populations and subsequently normalizing associated metabolic pathways. This microbiome-oriented perspective provides new insights into traditional herbal medicine mechanisms, emphasizing the critical need to understand microbiota-mediated therapeutic strategies in gastrointestinal disorders.
Authors
- Yiran Jin
- Wenyu Li (ORCID: https://orcid.org/0000-0003-0218-589X)
- Qian Zhang (ORCID: https://orcid.org/0000-0003-3984-1117)
- Ming Wang (ORCID: https://orcid.org/0009-0001-1922-6363)
- Huiyi Zhang (ORCID: https://orcid.org/0000-0002-2345-9573)
- Weiwei Xie
- Yingfeng Du
- Nan Wang (ORCID: https://orcid.org/0009-0003-9735-4314)
Institutions
- Hebei Medical University (CN)
- Second Hospital of Hebei Medical University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fmicb.2025.1634410
- Citations
- 3
- Primary Topic
- Ginseng Biological Effects and Applications
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- Natural Science Foundation of Hebei Province