A machine learning-derived immune-related prognostic model identifies PLXNA3 as a functional risk gene in colorectal cancer
This study identifies <i>PLXNA3</i> as a novel immune-related biomarker in colorectal cancer and elucidates its multifaceted role in tumor progression, immune evasion, and therapeutic resistance. These findings provide a foundation for incorporating <i>PLXNA3</i> into precision oncology frameworks for gastrointestinal malignancies.
Authors
- Wen‐chang Lin (ORCID: https://orcid.org/0000-0003-0194-1745)
- Chenshen Huang (ORCID: https://orcid.org/0000-0001-6107-8264)
- Fangqin Xue (ORCID: https://orcid.org/0000-0003-2418-3553)
- Guodong Guo (ORCID: https://orcid.org/0000-0001-9583-0055)
- Qi Huang (ORCID: https://orcid.org/0000-0001-8734-1681)
- Li Liu (ORCID: https://orcid.org/0000-0003-3022-936X)
- Hong Chen (ORCID: https://orcid.org/0000-0001-8054-7417)
- Song Wang (ORCID: https://orcid.org/0000-0003-4977-1327)
- Chao Xu (ORCID: https://orcid.org/0000-0002-0302-357X)
- Hanzhang Lyu (ORCID: https://orcid.org/0000-0003-2844-3746)
Institutions
- Tongji University (CN)
- Fujian Medical University (CN)
- Fujian Provincial Hospital (CN)
- Tongji Hospital (CN)
- Shanghai Zhabei District Shibei Hospital (CN)
- Fuzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1653794
- Citations
- 1
- Primary Topic
- Ferroptosis and cancer prognosis
- Type
- article
- Field-Weighted Citation Impact
- 1.52