Intratumoral bacterial load and tertiary lymphoid structure density in hepatocellular carcinoma: association and prognostic significance
Our study demonstrates that patients receiving structured TME and excluded TME subtypes exhibit superior overall survival (OS) and recurrence-free survival (RFS) following radical surgery. Furthermore, the intratumoral bacterial load showed a significant correlation with CD20+ B-cell density and was strongly correlated with both the number and maturity of TLS. These findings suggest that intratumoral bacteria may influence patient responses to immunotherapy.
Authors
- Weili Jia (ORCID: https://orcid.org/0000-0001-5045-8835)
- Wenjie Song
- Chaosheng Peng
- Ye Nie (ORCID: https://orcid.org/0000-0002-2887-707X)
- Qianyun Yao
- Xiaoyan Liu (ORCID: https://orcid.org/0000-0002-1732-5923)
- Chao Chen (ORCID: https://orcid.org/0000-0002-4422-1716)
- Yangang Wang (ORCID: https://orcid.org/0000-0001-6597-420X)
- Zexu Yang
- Zihao Zhao (ORCID: https://orcid.org/0000-0001-6485-4484)
- Feng Chang
- Shen Qu
Institutions
- Lanzhou University of Technology (CN)
- Xi'an Medical University (CN)
- Xijing Hospital (CN)
- Lanzhou University (CN)
- Air Force Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1652433
- Citations
- 2
- Primary Topic
- Cancer Immunotherapy and Biomarkers
- Type
- article
- Field-Weighted Citation Impact
- 2.09