Dysregulated tryptophan metabolism: driving T cell subsets and PI3K-Akt pathway alterations in Hashimoto’s thyroiditis
Trp metabolism abnormality is associated with HT. Trp supplementation can alleviate HT progression by regulating T cell function and the PI3K-Akt pathway, while inhibiting Trp metabolism exacerbates it. This suggests Trp metabolism's potential as a therapeutic target for HT.
Authors
- Qiong Wang (ORCID: https://orcid.org/0000-0002-6898-6879)
- Tingcai Cheng (ORCID: https://orcid.org/0000-0002-3862-0817)
- Xinrui Zhou (ORCID: https://orcid.org/0000-0002-4079-6475)
- Lijian Zhang (ORCID: https://orcid.org/0000-0003-3881-7705)
- Xiaoyan Pei (ORCID: https://orcid.org/0000-0001-5404-8614)
- Lei Yu (ORCID: https://orcid.org/0000-0001-7246-8305)
- Guoxi Jin
Institutions
- First Affiliated Hospital of Bengbu Medical College (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1605739
- Citations
- 1
- Primary Topic
- Immune Cell Function and Interaction
- Type
- article
- Field-Weighted Citation Impact
- 0.80