Developing models for the diagnosing of ulcerative colitis and prognosis of anti-TNF-α non-response based on neutrophil extracellular trap-associated genes
A distinct NET-associated cluster was identified among patients with UC, exhibiting non-responsiveness to anti-TNF-α treatment. Diagnostic and prognostic models based on NET-associated genes hold promise for guiding clinical treatment strategies.
Authors
- Fachao Zhi (ORCID: https://orcid.org/0000-0001-8674-4737)
- Linzhen Li (ORCID: https://orcid.org/0000-0003-2406-9160)
- Bing Huang (ORCID: https://orcid.org/0000-0002-6408-2653)
- Xinmei Zhao (ORCID: https://orcid.org/0000-0003-3940-788X)
- Jinyuan Ou
Institutions
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- Southern Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1530508
- Citations
- 1
- Primary Topic
- Neutrophil, Myeloperoxidase and Oxidative Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 0.80
Funders
- National Natural Science Foundation of China
- Southern Medical University
- Nanfang Hospital
- Basic and Applied Basic Research Foundation of Guangdong Province