Combined metagenomic and metabolomic analyses reveal gut microbiota dysbiosis and metabolic dysfunction in pediatric neurodevelopmental disorders
Collectively, our study presents the first integrated profile of gut microbiome, microbial metabolites, and host metabolome, reveals gut microbiota dysbiosis, functional impairment, and metabolic disturbance in pediatric NDDs. These findings provide a theoretical foundation for microbiotaand metabolite-targeted therapeutic strategies in childhood NDDs.
Authors
- Yongwen Luo (ORCID: https://orcid.org/0000-0002-8724-6550)
- Xuesong Xiang
- Qi Wang (ORCID: https://orcid.org/0009-0008-6104-3115)
- Juanjuan Chen (ORCID: https://orcid.org/0000-0001-8390-8951)
- Chunmei Mao
Institutions
- Chinese Center For Disease Control and Prevention (CN)
- National Health and Family Planning Commission (CN)
- Gansu Provincial Hospital (CN)
- Lanzhou University Second Hospital (CN)
- Lanzhou University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1645137
- Citations
- 2
- Primary Topic
- Gut microbiota and health
- Type
- article
- Field-Weighted Citation Impact
- 1.61
Funders
- Lanzhou University
- Natural Science Foundation of Gansu Province