Dendritic cells in the human vaginal mucosa can direct CD4+ T cell responses by expressing surface OX40L
OX40L contributes to vLC- and CD1c<sup>+</sup>CD14<sup>-</sup> vDC-induced Th2 polarization. It also significantly affects the frequency of vLC- and CD1c<sup>+</sup>CD14<sup>-</sup> vDC-induced IL - 10<sup>+</sup> and IL - 21<sup>+</sup>CD4<sup>+</sup> T cells. This study provides new insights into the immunological landscape of the human VM tissues, with implications for the development of targeted immunomodulatory strategies at this mucosal site.
Authors
- Johnny Yi (ORCID: https://orcid.org/0000-0002-7480-6344)
- SangKon Oh (ORCID: https://orcid.org/0000-0003-0813-5244)
- HyeMee Joo
- Dorothée Duluc (ORCID: https://orcid.org/0000-0002-7252-9072)
- Laurie Baert (ORCID: https://orcid.org/0000-0001-8309-7132)
- Agnes Yang
Institutions
- Centre National de la Recherche Scientifique (FR)
- Université de Bordeaux (FR)
- Immunology from Concept and Experiments to Translation (FR)
- Mayo Clinic in Arizona (US)
- Mayo Clinic Hospital (US)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1657115
- Citations
- 1
- Primary Topic
- Dermatology and Skin Diseases
- Type
- article
- Field-Weighted Citation Impact
- 2.00
Funders
- National Institutes of Health