Population pharmacokinetic modeling of dexmedetomidine nasal spray in Chinese adults
The present analysis successfully established a PopPK model for dexmedetomidine nasal spray in Chinese adults, confirming that body weight influences distribution and clearance. This PopPK model is being further explored to support pediatric dose recommendation.
Authors
- Nassim Djebli (ORCID: https://orcid.org/0000-0003-3333-2979)
- Hao Jiang (ORCID: https://orcid.org/0000-0001-8528-1777)
- Guoping Yang (ORCID: https://orcid.org/0000-0001-5930-586X)
- Yuanyuan Huang (ORCID: https://orcid.org/0000-0003-4202-8071)
- Sheng Xu (ORCID: https://orcid.org/0000-0003-3756-497X)
Institutions
- Central South University (CN)
- Princeton University (US)
- Jiangsu Hengrui Medicine (China) (CN)
- Third Xiangya Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fphar.2025.1662364
- Citations
- 2
- Primary Topic
- Anesthesia and Sedative Agents
- Type
- article
- Field-Weighted Citation Impact
- 4.38