TLR2 and IRF8 are the biomarkers associated with hypoxia in steroid-induced osteonecrosis of the femoral head via bioinformatics analysis and experimental validation
TLR2 and IRF8 might act as promising biomarkers for SONFH patients. The findings would offer new insights for identifying potential biomarkers and drug targets for SONFH.
Authors
- Biaofang Wei (ORCID: https://orcid.org/0000-0002-0861-0685)
- Junfang Wang (ORCID: https://orcid.org/0000-0003-3670-5398)
- Jing Zhang (ORCID: https://orcid.org/0000-0001-5516-633X)
- Jing Guo (ORCID: https://orcid.org/0009-0005-8497-9758)
Institutions
- Qingdao University (CN)
- Guangzhou University of Chinese Medicine (CN)
- Linyi People's Hospital (CN)
- Jinan Central Hospital (CN)
- Affiliated Hospital of Qingdao University (CN)
- Shandong First Medical University (CN)
Publication Details
- Journal
- BMC Musculoskeletal Disorders
- Published
- 2025-09-02
- DOI
- https://doi.org/10.1186/s12891-025-09132-7
- Primary Topic
- Bone and Joint Diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00