Soluble immune checkpoint factors reveal high-risk osteosarcoma subtypes and enable early metastasis prediction
Soluble immune checkpoint factors were identified as significantly associated with osteosarcoma metastasis. Using peripheral blood biomarkers, we characterized immune subtypes of osteosarcoma, and developed a predictive model for metastasis. These biomarkers may serve as potential therapeutic targets for future immunotherapy.
Authors
- Qinchuan Wang (ORCID: https://orcid.org/0000-0002-2359-3262)
- Hanqi Peng
- Guohui Sun (ORCID: https://orcid.org/0000-0002-6586-9458)
- Jiameng Cui (ORCID: https://orcid.org/0000-0002-7902-5942)
- Xifeng Wu (ORCID: https://orcid.org/0000-0001-5174-3769)
- Binghao Li (ORCID: https://orcid.org/0000-0001-8565-7287)
- Huakang Tu (ORCID: https://orcid.org/0000-0002-8494-7327)
- Zhaoming Ye (ORCID: https://orcid.org/0000-0001-5951-5840)
- Sicong Wang (ORCID: https://orcid.org/0000-0001-8709-0237)
- Yun Zhu
Institutions
- Sir Run Run Shaw Hospital (CN)
- Zhejiang Lab (CN)
- Second Affiliated Hospital of Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1651051
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00