Parthanatos drives cognitive decline in repeated brain trauma: MSC-derived exosomes as a novel therapeutic strategy
Overall, these findings demonstrate that MSC-derived exosomes counteract RTBI-induced neurodegeneration through multifaceted mechanisms, with parthanatos suppression at the core. Importantly, the dual-dosing regimen conferred no significant benefit over the single dose, highlighting the therapeutic promise of early intervention. This study positions MSC-derived exosomes as a novel, cell-free therapy capable of intercepting RTBI-induced neuropathology by targeting an under recognized form of programmed cell death.
Authors
- Hagar B. Abo-Zalam (ORCID: https://orcid.org/0000-0002-9295-8739)
- Hanan S. El‐Abhar (ORCID: https://orcid.org/0000-0001-8819-9891)
- Abhijna Ballal R (ORCID: https://orcid.org/0000-0003-0165-8042)
- Heba Mohammed Refat M. Selim (ORCID: https://orcid.org/0000-0001-6973-6460)
- Sultan Alshehri (ORCID: https://orcid.org/0000-0002-0922-9819)
- Asmaa Saleh (ORCID: https://orcid.org/0000-0002-6286-319X)
- Ghada M. Ragab (ORCID: https://orcid.org/0000-0002-6343-8507)
- Amira A. El-Gazar (ORCID: https://orcid.org/0000-0002-8372-4682)
- Ahmed N. Abdallah (ORCID: https://orcid.org/0000-0003-0517-6470)
- Einas Yousef (ORCID: https://orcid.org/0000-0002-8935-0183)
- Dalaal M. Abdallah (ORCID: https://orcid.org/0000-0001-5876-5530)
- Rasha A. Mandil
- Naheda S. Alsammak (ORCID: https://orcid.org/0009-0001-7827-0233)
- Sahar N. Aljarallah
- Nada F. Abou Chahin
- Rabab A. El-Gazar
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Alfaisal University (SA)
- Cairo University (EG)
- Misr University for Science and Technology (EG)
- King Saud University (SA)
- National Research Centre (EG)
- October 6 University (EG)
- Almaarefa University
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fphar.2025.1622018
- Citations
- 1
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- AlMaarefa University
- Princess Nourah Bint Abdulrahman University
- Alfaisal University