Association between acetaminophen use and 30-day mortality in critically ill patients with pulmonary embolism: a retrospective cohort study using the MIMIC-IV database
acetaminophen use was associated with reduced 30-day mortality in critically ill patients with PE, with temperature control appearing to play a potential mediating role. These preliminary findings provide hypothesis-generating evidence that warrants validation in prospective randomized controlled trials before clinical implementation.
Authors
- Liman Qiu (ORCID: https://orcid.org/0000-0003-4332-1843)
- Xiankun Lin (ORCID: https://orcid.org/0000-0001-6936-4812)
- Xunwei Tu
- Lingling Jiang (ORCID: https://orcid.org/0000-0002-0899-5861)
- Long Huang (ORCID: https://orcid.org/0000-0003-3810-9178)
- Xiuling Shang (ORCID: https://orcid.org/0000-0002-5390-6733)
- Xincai Wang (ORCID: https://orcid.org/0000-0001-7098-770X)
Institutions
- Fujian Medical University (CN)
- Mengchao Hepatobiliary Hospital (CN)
- Fujian Provincial Hospital (CN)
Publication Details
- Journal
- Frontiers in Pharmacology
- Published
- 2025-09-02
- DOI
- https://doi.org/10.3389/fphar.2025.1663773
- Primary Topic
- Venous Thromboembolism Diagnosis and Management
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Fujian Province
- Fujian Medical University